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University of Bern
Department of
Clinical Research
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Murtenstrasse 35
CH-3010
Bern, Switzerland
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Laboratory of
Phytopharmacology, Bioanalytics &
Pharmacokinetics
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Group Prof. R.
Brenneisen
Address:
Prof. Dr. Rudolf
Brenneisen
Department of
Clinical Research, University of Bern,
Murtenstrasse 35,
CH-3010 Bern, Switzerland
Phone / Fax:
++41-(0)31-63 287
14
/
++41-(0)31-63 232 97
E-Mail:
rudolf.brenneisen@dkf.unibe.ch
Group members:
Rudolf Brenneisen, PhD, Professor, Head
CV:
1975
Federal Diploma
(M.S.)
for Pharmaceutical Sciences, University of Bern (UNIBE); 1979 Ph.D. for
Phytochemistry
& Pharmacognosy, UB (Prof. E. Steinegger); Assistant Professor for
Phytochemistry
& Pharmacognosy (Research & Teaching), Institute of Pharmacy,
UNIBE;
1981 Head of the Dept. of Phytochemistry & Pharmacognosy, Institute
of
Pharmacy, UNIBE; 1987 Visiting Research Scientist at the University of
Mississippi,
School of Pharmacy, Research Institute of Pharmaceutical Sciences
(Prof.
M.A. ElSohly);1988 Habilitation at the Faculty of Medicine,
UNIBE,
for
"Pharmaceutical Phytochemistry & Pharmacognosy"; Privatdozent (PD)
for
"Pharmaceutical Phytochemistry & Pharmacognosy"; 1989- Consultant/
Expert,
United Nations International Drug Control Programme (UNDCP); 1990-91
Vice-Director,
Institute of Pharmacy, UNIBE; 1993 Associated Professor, UNIBE; 1993-
Consultant/Expert,
Federal Office of Public Health, Div. of Pharmaceuticals &
Narcotics;
1993- Member of the Swiss Guideline Committee for Drug Abuse Testing
(AGSA);
1994-96
Head of the Analytical Toxicology Unit, Institute of Pharmacy, UNIBE;
1997-
Head of the „Laboratory for Pharmaceutical Analysis,
Pharmacokinetics
and Toxicology“, Dept. of Clinical Research (DKF), UNIBE; 1997-2007 Member of the
scientific
advisory board of the „International Association of Cannabis as
Medicine
(IACM)“; 2006- Member of the
scientific advisory board of "Cannabinoids" (IACM);
2007- Member of the advisory committee of the "Journal of
Phytopharmacotherapy and Natural Products".(JPNP);
2009- Member of the executive board
of
directors
of the „International Association of Cannabis as
Medicine (IACM); 2007- Member of the Scientific
Council of the Swiss Society of Pharmaceutical Sciences, SGPhW (SSPhS); 2008- President Scientific Advisory Board of
The Swiss Academy of Pharmaceutical
Sciences, SAPhS; Advisory Board Swiss ALS Association (A LS); President
Swiss Committee for Drugs of Abuse Testing SCDAT (SCDAT).
Memberships:
Society for
Medicinal
Plant Research (GA);
American Academy of Forensic Sciences (AAFS),
Section
of Toxicology (Fellow); The International Association of Forensic
Toxicologists
(TIAFT); The Society of
Forensic Toxicologists (SOFT);
German
Association
of Toxicology and Forensic Chemistry (GTFCh);
Society of Swiss
Pharmacists;
Society of Bernese Pharmacists (honorary member); Swiss Society for
Pharmaceutical Sciences
(SGPhW); European Workplace Drug Testing
Working Group/Soc. (EWDTG/EWDTS); The International Cannabinoid
Research Society (ICRS).
Main
research interests:
see
below.
Christian
Lanz, PhD, Pharmacist, Lab Supervisor
(starting mid of August 2010)
Sandrine Gouinguené, PhD
2006-2007 Philip Morris International,
Neuchâtel, Switzerland, Scientist; 2002-2005 Agroscope Wädenswil, Switzerland.
Post-Doc. Selection by insects of host-plant mediated by the perception
of secondary substances? A key to understand the evolution of
host-plant specialisation; 2001 Integrated
Approach to Crop Research (IACR), Harpenden, UK. Post-Doc
Electrophysiological responses of 3 parasitic wasps to induced odour of
plants; 2000-1996 PhD in Biology, Laboratory of
Animal Ecology and Entomology, Specificity
and variability of induced signal by maize plants, University
of Neuchâtel, Switzerland; 1996-1995
Master degree in Physical-Chemistry and Quality of Bio products, INAPG,
Paris, France; 1995-1992 Engineer Degree in
Food Science. ENITIAA,
Nantes, France.
Kathrin Suter, MSc, Pharmacist, PhD
Student
(starting July 2010)
Academics and technicians from DKF-BNF
Programs
Ursula Kunz, Technician
2007 -
2008 Lab Tech, Chemistry Dept., Bern; 1999
- 2001 Study Nurse, Cardiology, University Hospital,
Bern; 1988 Medical
Assistent, DVSA, Zürich; 1985 - 1986 Lab Tech, Institute of
Forensic Chemistry,
Basel; 1976 - 1979 Apprentice in Chemistry Lab,
Ciba-Geigy,
Basel
Open positions
(On request)
Main research interest:
Pharmacology and clinical studies of
natural and synthetic drugs, mainly cannabinoids and opioids.
Endocannabinoid system.
Development
of pulmonal
applications forms.
Heroin maintenance
and substitution programs.
Development and validation
of chromatographic-spectroscopic methods for
pharmacological,
toxicological
and pharmaceutical applications.
Cannabis
profiling (chemical fingerprinting).
Monitoring
of
drugs in body fluids, Bioanalytics.
Pharmacokinetic profiling
and metabolism of drugs and drugs of abuse.
Ethnopharmacognosy and
-pharmacology of medicinal plants.
Psychoactive drugs in psychotherapy.
Instrumentation:
High-performance liquid chromatograph
with diode-array detection (HPLC-DAD)
Gas
chromatograph with flame ionization and phosphorus/nitrogen detection
(GC-FID/NPD)
Gas chromatographs with mass spectrometric detection (GC/MS/EI-CI)
Automated
Solid
Phase Extractor (ASPEC)
Preparative Medium Pressure Liquid Chromatograph (MPLC)
Diode-array spectrophotometer (DAD).
Ongoing projects (status June 2010):
In vitro and
in vivo validation of cannabinoid aerosols for pulmonal
application.
Pharmacokinetics
of THC in ALS patients.
Function of phyto- and endocannabinoids in liver diseases.
Phytochemistry,
pharmacology and clinics of Bryophyllum species.
Bioanalytical monitoring of heroin by-consumption
in a
morphine-methadone substitution therapy program.
Trace analysis of organic sewage contaminants in the Bernese Aare river
focussing on pharmaceuticals.
LSD as adjunct in psychotherapy.
(Psycho)pharmacology and pharmacokinetics of MDMA.
(Psycho)pharmacology and pharmacokinetics of diacetylmorphine.
Selected
references 2008-2010:
M. Kosel, R.S.
Noss,
R. Hämmig, P. Wielepp, P. Bundeli, R. Heidbreder, J.A. Kinser, R.
Brenneisen, H.-U. Fisch, S. Kayser, T.E. Schlaepfer.
Cerebral
blood flow effects of acute intravenous heroin administration.
Eur.
Neuropsychopharmacol. 2008; 18: 278-285.
P. Netzer, A. Sendensky, M. Wissmeyer, S. Baumeler, C. Batista, U.
Scheurer, T. Krause, P. Reber, and R. Brenneisen.
The effect of
naloxone-3-glucuronide on colonic transit time in healthy men after
acute morphine administration: a placebo-controlled double-blinded
crossover preclinical volunteer study.
Aliment. Pharmacol. Therap.
2008; 28: 1334-41.
P. Bigler, R. Brenneisen.
Improved impurity fingerprinting of heparin
by high resolution 1H-NMR spectroscopy.
J. Pharm. Biomed. Anal., 2009;
49: 1060-64.
Simoes-Wüst AP, Graos M, Duarte CB, Brenneisen R, Hamburger M,
Mennet M, Ramos F MH, Schnelle M, Wächter R, Worel AM, von Mandach
U.
Juice of Bryophyllum pinnatum (Lam.) inhibits oxytocin-induced increase
of the intracellular clacium concentration in human myometrial cells
(In press).
Mareck U,
Haenelt N, Geyer H, Guddat S, Kamber M, Brenneisen
R, Thevis M, Schänzer W.
Temporal
indication of cannabis use by means of THC
glucuronide determination.
Drug Test. Analysis 2009; 1: 505-510.
Brenneisen R, Meyer P,
Chtioui H, Saugy M, Kamber M.
Plasma and urine
profiles of delta-9-tetrahydrocannabinol (THC) and its metabolites
11-hydroxy-THC and 11-nor-9-carboxy-THC after cannabis smoking by
healthy volunteers
to estimate recent consumption of athletes.
Anal.
Bioanal. Chem. 2010; 396: 2493-2502.
Events:
Swiss
Pharma Science Day 2008 (SPhSD 2008)
Swiss
Pharma Science Day 2009 (SPhSD 2009)
==> Swiss
Pharma Science Day 2010 (SPhSD 2010) <==
University
of Bern, 8. September
2010
Program
Links:
Swiss
Guidelines Committee for Drugs of Abuse Testing (SCDAT): Guidelines
(german, french, english)
Swiss
Society of Pharmaceutical Sciences
(SSPhS)
Schweizerische
Gesellschaft für Geschichte der Pharmazie (SGGP)
International
Association for Cannabis as
Medicine (IACM)
The International Cannabinoid
Research Society (ICRS)
Society
for Medicinal Plant Research
(GA)
Location:
Site manager: R. Brenneisen
Updated: 220610
